C-5 Hydroxyethyl and Hydroxypropyl Acyclonucleosides as Substrates for Thymidine Kinase of Herpes Simplex Virus Type 1 (HSV-1 TK): Syntheses and Biological Evaluation

The efficient syntheses of 5-(2-hydroxyethyl)- and 5-(3-hydroxypropyl)-substituted pyrimidine derivatives bearing 2,3-dihydroxypropyl, acyclovir-, ganciclovir- and penciclovir-like side chains are reported.A synthetic approach that included the alkylation of an N-anionic-5-substituted pyrimidine intermediate (method A) provided the Treats Packaged

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Lithium carbonate as add-on therapy to radioiodine in the treatment on hyperthyroidism: a systematic review and meta-analysis

Abstract Background The main purpose is to investigate the effect of LiCO3 as an add-on therapy with radioactive iodine in increasing the cure and decreasing the T4 level compared Lighting to radioactive iodine alone.The primary outcome is the cure rate as defined by the number of hyperthyroid patients who became euthyroid or hypothyroid.The second

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Case Report of Concomitant Diagnosis of Locally Advanced Intrahepatic Cholangiocarcinoma and Solitary Plasmacytoma of T11 Vertebra: Impact on Diagnostic and Clinical Management

A solitary bone plasmacytoma is a rare tumor.Intrahepatic cholangiocarcinoma is the second most common primary liver cancer after hepatocellular carcinoma.We present the case of a 48-year-old female patient who consulted for recent back pain, with a final diagnosis of T10 solitary plasmacytoma and synchronous intrahepatic Hot Wheels cholangiocarcin

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Direction-of-Arrival Estimation for Unmanned Aerial Vehicles and Aircraft Transponders Using a Multi-Mode Multi-Port Antenna

Increasing airspace safety is an important challenge, both for unmanned aerial vehicles (UAVs) as well as manned aircraft.Future developments of collision avoidance systems are supposed to utilize information from multiple sensing systems.A compact sensing system could employ a multi-mode multi-port antenna (M 3PA).Their ability Lighting to radiate

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